ECUACION MICHAELIS MENTEN PDF

Jump to navigation Jump to search This article is about the Hill equation as an equation used in biochemical characterization. For other uses, see Hill differential equation. Binding curves showing the characteristically sigmoidal curves generated by using the Hill-Langmuir equation to model cooperative binding. The vertical axis displays the proportion of the total number of receptors that have been bound by a ligand. The horizontal axis is the concentration of the ligand.

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Jump to navigation Jump to search This article is about the Hill equation as an equation used in biochemical characterization. For other uses, see Hill differential equation. Binding curves showing the characteristically sigmoidal curves generated by using the Hill-Langmuir equation to model cooperative binding.

The vertical axis displays the proportion of the total number of receptors that have been bound by a ligand. The horizontal axis is the concentration of the ligand.

As the Hill coefficient is increased, the saturation curve becomes steeper. In biochemistry and pharmacology , the Hill equation refers to two closely related equations that reflect the binding of ligands to macromolecules, as a function of the ligand concentration. A ligand is "a substance that forms a complex with a biomolecule to serve a biological purpose" ligand definition , and a macromolecule is a very large molecule, such as a protein, with a complex structure of components macromolecule definition.

Protein-ligand binding is an example of this kind of binding, which typically changes the structure of the target protein, thereby changing its function in a cell. The distinction between the two Hill equations is whether they measure occupancy or response. The Hill-Langmuir equation reflects the occupancy of macromolecules: the fraction that is saturated or bound by the ligand.

The Hill-Langmuir equation was originally formulated by Archibald Hill in to describe the sigmoidal O2 binding curve of haemoglobin.

The Hill-Langmuir equation is useful for determining the degree of cooperativity of the ligand s binding to the enzyme or receptor. The Hill coefficient provides a way to quantify the degree of interaction between ligand binding sites.

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Ecuación de Michaelis-Menten (Deducción)

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