Gen Comp Endocrinol. Epub May 9. Antifertility efficacy of Coccinia indica in male mice and its possible mechanisms of action on spermatogenesis. Electronic address: shioks rediffmail.
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Corresponding author. E-mail:Email: moc. Copyright , Mary Ann Liebert, Inc. Abstract Diabetic nephropathy is one of the secondary complications of diabetes mellitus that is marked by changes in extracellular matrix components leading to end-stage renal failure.
Diet plays an important role in managing diabetes. In the present study, the effect of Coccinia indica consumption on diabetes-mediated kidney damage was determined. Both control and diabetic rats were fed with AIN diet supplemented with C. Various parameters, such as fasting blood glucose, urine sugar, albumin excretion, kidney index, and glomerular filtration rate, were ameliorated to various extents by the supplementation of C.
Additionally, diabetic rats fed with diet supplemented with C. They also exhibited beneficial effects on key antioxidant enzymes of the kidney. Furthermore, an increase in laminin and fibronectin as a result of diabetes was alleviated in C. These results indicate that the consumption of C.
Key Words: albumin excretion, Coccinia indica, diabetes mellitus, extracellular matrix components, kidney index Introduction Diabetes mellitus is one of the major causes of morbidity and mortality worldwide. Diabetic nephropathy is characterized by renal enlargement accompanied by marked changes in extracellular matrix ECM components.
Remodeling of ECM components of the kidney in diabetic conditions is known to affect the filtration process. There are various causes of development of diabetic nephropathy. Accumulating evidence suggests that free radicals, such as reactive oxygen species ROS and formation of advanced glycation end products, lead to the activation of various signaling factors, thereby bringing about changes in ECM components in the kidney.
Studies from our laboratory have shown that dietary components are efficient in containing diabetes-mediated complications, thereby helping maintain general health. Various dietary components, such as wheat bran and guar gum, butyric acid, the product obtained by anaerobic digestion of dietary fiber, fenugreek, and spent turmeric, have been shown to ameliorate the diabetic condition to various extents, imparting beneficial effects on the kidney.
It is a climbing perennial herb, growing throughout India especially in warmer and humid climatic conditions. It is widely used in traditional treatment of diabetes. Scientific investigations have supported the efficacy of leaf extracts in amelioration of diabetic conditions. Antibodies to laminin and fibronectin, and secondary antibodies conjugated to ALP were obtained from Abcam. Accu-Chek glucometer strips were obtained from Roche Diagnostics.
All other chemicals used were of analytical grade. Plant materials C. They were washed in running tap water and drained. The dried plant materials were powdered and stored in airtight containers in a refrigerator until use. Analytical methods The dietary fiber content was analyzed by the enzymatic—gravimetric method.
Gas-liquid chromatography GC analyses of the hydrolyzed samples were carried out by derivatizing the sugars. The extracted mixture was centrifuged at g for 10 min. The supernatant was collected and filtered. The amount of phenolics was estimated as reported earlier. The animals were housed in individual cages with free access to food and water. Preparation of diet Diet AIN was freshly prepared.
Grouping of animals and induction of diabetes mellitus Rats were initially grouped into A and B based on the body weight. The control groups had 6 animals and the diabetic groups had 11 animals each at the start of the study. After 2 months of experimental period, there were seven, eight, and eight animals in the SFD, CFD, and CLD groups, respectively, and six animals each in the control groups. Urine of 24 h duration was collected over a layer of toluene by keeping them in metabolic cages.
Reducing sugar in urine was measured by the dinitrosalicylic acid method. The blood glucose level was measured using a glucometer. The area under the curve AUC was calculated using the trapezoidal rule. The homogenates were centrifuged at 31, g for 15 min, and an aliquot of supernatant was taken for the analyses. The catalase activity was assayed by following the rate of decomposition of hydrogen peroxide as described by Aebi.
The fold changes in ECM components were determined by comparing nondiabetic control rats. Results Determination of dietary fiber, total sugar, uronic acid, and analysis of neutral sugars by gas-liquid chromatography C. Fruits had slightly more soluble fiber than leaves. GC analysis of the whole fruit and leaf powder for neutral sugars showed the presence of arabinose, xylose, mannose, galactose, and glucose as major sugars in fruit, whereas leaves also contained rhamnose data not shown.
Effect of Coccinia Cordifolia Extract on Blood Sugar of Newly Diagnosed Diabetics
Coccinia Indica plant has been used in India centuries before as traditional medicine in Ayurveda and vegetable. The effect of Coccinia Indica as blood glucose and blood lipid-lowering medicinal plant has been demonstrated in numerous studies. This is attributed to the activity of plant substances which lactate dehydrogenize in glycol tic metabolism, and lipoprotein lipase - activity in the lipolytic pathway check and correct the activity of glucosephosphatase and support pancreas to work healthy and effectively. This effect was repeatedly in many international scientific work and publications is also documented and proven.
ALL ABOUT ANTIDIABETIC PLANT: COCCINIA INDICA
Corresponding author. E-mail:Email: moc. Copyright , Mary Ann Liebert, Inc. Abstract Diabetic nephropathy is one of the secondary complications of diabetes mellitus that is marked by changes in extracellular matrix components leading to end-stage renal failure. Diet plays an important role in managing diabetes. In the present study, the effect of Coccinia indica consumption on diabetes-mediated kidney damage was determined.
Drug: Coccinia Cordifolia herbal extract Not Applicable Detailed Description: The prevalence of diabetes is increasing in all countries, especially India at an alarming rate. Appropriate interventions in the form of weight reduction, changes in dietary habits and increased physical activity could help in preventing or delaying the onset of diabetes and reducing the burden due to non communicable diseases in India. Plants or their extracts may also have a potential therapeutic role in the treatment for diabetes. Coccinia indica synonym Coccinia cordifolia , a herb that belongs to the Cucurbitaceae family and that grows abundantly in India, is widely used in the traditional treatment of diabetes mellitus. Coccinia leaves, when administered orally twice a day for six weeks, to patients with untreated but uncomplicated maturity onset diabetes demonstrated hypoglycemic activity with significant improvement in glucose tolerance. The aim of the present study was to evaluate the effectiveness of Coccinia Cordifolia on the blood glucose levels of newly detected type 2 diabetic patients requiring only behavioral or lifestyle intervention.
Information about Coccinia Indica Coccinia Indica scarlet vine is a climbing, herbaceous, branched plant that grows in India spread far. For many centuries Coccinia Indica, India as part of Ayurvedic medicine to reduce blood sugar and is therefore used for centuries an important part of Indian traditional medicine. This herbal product is blood sugar and blood fat-lowering properties and thus is suitable for supporting and therapeutic applications for blood sugar control, reduce insulin resistance and to reduce late complications in diabetes mellitus. Coccinia Indica in a natural way to lower blood sugar. Coccinia Indica was targeted to treat diabetes mellitus and its late effects used to. Besides these contains minerals like calcium, Iron and phosphorus.