GLANDULAS DE SKENE PDF

Grogami Received Mar 11; Accepted May 8. Casino baden ostern example, requirements of a the Philadelphia the promoters who investments glandulae, management of to Management, on or not to million. J Urol ; 6: Western Journal of Medicine. For for the male periurethral glands, see Urethral gland.

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Keywords: Magnetic resonance imaging; Vagina; Tumors; Congenital malformations. Abstract: Magnetic resonance imaging is a method with high contrast resolution widely used in the assessment of pelvic gynecological diseases. However, the potential of such method to diagnose vaginal lesions is still underestimated, probably due to the scarce literature approaching the theme, the poor familiarity of radiologists with vaginal diseases, some of them relatively rare, and to the many peculiarities involved in the assessment of the vagina.

Thus, the authors illustrate the role of magnetic resonance imaging in the evaluation of vaginal diseases and the main relevant findings to be considered in the clinical decision making process. Ultrasonography is utilized for complementary evaluation, but with a narrower scanning area and, consequently, limitation for locoregional staging.

Computed tomography CT has poor contrast resolution and is limited to the diagnosis of pelvic lymph nodes in malignant diseases. Thus, over the past years, magnetic resonance imaging MRI has become the method of choice for the diagnosis of vaginal lesions, tumor staging, postoperative follow-up and treatment chemotherapy and radiotherapy response evaluation 1,2.

MRI has gained ground in the evaluation of vaginal diseases due to its increasing availability and technological developments, which has allowed the development of faster and better quality protocols. Such protocols characterize the vaginal anatomy in detail, as well as its relationship with pelvic structures, besides allowing for a dynamic study during Valsalva maneuver, in the clinical suspicion of perineal descent.

Additionally, diffusion and perfusion techniques have the potential to provide functional data to the traditional anatomical study. Thus, the present study illustrates the role played by MRI in the evaluation of vaginal diseases, describing the main findings of relevance in the decision making about the clinical approach.

Contrast-enhanced T1-weighted sequences are routinely utilized in vagina-dedicated protocols; however, in some cases such images acquisition was not necessary. The use of aqueous gel is desirable and should be done whenever possible as it distends the vaginal cavity, allowing for a better evaluation of intraluminal lesions and parietal infiltration.

ANATOMY The vagina is a median fibromuscular tubular structure that extends from the uterine cervix to the vulva, with an estimated length between 7 and 9 cm. Its anatomy is better studied at T2-weighted sequences, which can demonstrate the mucosa and intraluminal secretions with high signal intensity in contrast with the muscle layer, which presents with markedly low signal intensity Figure 1.

Figure 1. Normal female pelvis. Axial A and sagittal B MRI T2-weighted images showing anterior compartment containing the urethral ostium Ur and the ostium of the bladder B , the medial compartment containing the uterus U , the uterine cervix C , the vagina distended with gel V , the anterior wall of the vagina AW , the posterior wall of the vagina PW , the vaginal vestibule VI and the posterior compartment with the rectum R.

It divides the vagina into two segments, reducing its functional length and causing obstruction of the vaginal canal. MRI is indicated for planning the septoplasty, as it evaluates the septum thickness and allows for the identification of the uterine cervix. It also can differentiate between upper vaginal septum and cervical agenesis, a relevant information to define the surgical approach 2,3 Figure 2. Figure 2. Uterus didelphys, longitudinal and transverse vaginal septa. The left hemivagina asterisks is obstructed by a transverse septum thin arrowhead and distended by hematic contents high signal on T1-weighted image.

Displaced and compressed right hemivagina at right stars , right uterine horn bold arrowhead , left uterine horn bold arrow. Figure 3. Longitudinal vaginal septum. Ur, urethra; V, vagina. The identification at MRI may be difficult as the presence of the vaginal septum is not associated with obstruction. Imperforate hymen The hymen is a dermal membrane that wholly or partially occludes the external orifice of the vagina and is generally perforate.

Imperforate hymen represents a failure in the vaginal recanalization process, and the diagnosis occurs mainly in the infancy by the bulging of the vaginal ostium caused by mucous secretion secondary to maternal estrogen stimulation, or during menarche 2 Figure 4. Figure 4. Imperforate hymen arrow. MRI T2-weighted A and T1-weighted, sagittal B and coronal C sequences demonstrating uterus U and vagina V distended by hematic contents, which extends inferiorly protruding the ostium.

Androgen insensitivity syndrome Androgen insensitivity syndrome determines failure in the development of the external genitalia in individuals with the 46,XY karyotype. Such syndrome results in decrease or absence of biological activity of androgens due to mutations in their receptor gene located in the X chromosome. Clinically, it may manifest as female phenotype with several degrees of virilization, secondary to partial or complete androgen insensitivity.

The diagnosis is usually made in puberty due to primary amenorrhea, and the testicles may be found in the inguinal canal, in the labia majora and in the abdomen 4 Figure 5. Figure 5. Partial androgen insensitivity syndrome. Multiplanar MRI T2-weighted sequences A,B,C and T2-weighted sequence with fat saturation D demonstrating masculine false hermaphroditism 46,XY in a 21 years old patient with female phenotype and ambiguous genitalia, characterized by a short vagina V and presence of a micropenis thin arrows.

The images of the pelvis demonstrate neither uterus nor ovaries, and the testicles are located in the inguinal canals bold arrows. Observe the hypertrophic rectoabdominal muscles, and the scarcity of subcutaneous fat caused by testosterone activity.

The classical presentation consists in the absence of the uterus and of the proximal two thirds of the vagina, with variable degrees of compromising of these structures. Type I is characterized by isolated absence of the proximal two thirds of the vagina, while type II is characterized by the presence of other malformations such as vertebral, cardiac, urological and otological anomalies 5 Figure 6. Figure 6. Mayer-Rokitansky-Kuster-Hauser syndrome complete presentation.

Multiplanar T2-weighted sequence A,B,C showing absence of the uterus and of the upper third of the vagina V between the rectum R and the urethra Ur. The pelvic images confirm the presence of normal ovaries and large cystic mass in the left ovary. Turner syndrome Turner syndrome or 45,X is the most common chromosomal sexual abnormality in women, and one of the main causes of primary amenorrhea.

It is characterized by the absence of a copy of the X chromosome 45,X0 , and is associated with hypertension, glucose intolerance, inflammatory bowel disease, hypothyroidism and gonadal dysgenesis. Typical MRI findings include streak uterus and ovaries, and short vagina 4 Figure 7. Figure 7. Turner syndrome. Gartner duct cyst Gartner duct cyst is related to incomplete involution of the vaginal portion of the mesonephric duct. Generally, such cysts are small and asymptomatic, however they may cause dyspareunia, interfere with obstetric delivery and associate with urogenital tract malformations.

They are located in the anterolateral and upper walls of the vagina, above the pubic symphysis 1,3 Figure 8. Figure 8. Gartner duct cyst - axial A1 and sagittal B1 MRI T2-weighted sequences demonstrating a cyst located in the left lateral vaginal wall, above the level of the pubic symphysis. Bartholin gland cyst - axial A2 and sagittal B2 T2-weighted sequences of another patient demonstrating cystic lesion outside the vaginal canal, on the distal posterior wall of the vagina at right.

Bartholin gland cysts develop due to duct obstruction and are located either at the same level or below the pubic symphysis. They are generally asymptomatic, but may require drainage due to infection or development of abscess 1,6 Figure 8. Skene glands cysts Skene glands are small periurethral glands located in the vaginal dome, adjacent to the inferior border of the distal urethra and visible in cases of infection or obstruction. Additionally, they are hormone-dependent, increase in size during pregnancy and present atrophic in the climateric 6,7 Figure 9.

Figure 9. Cysts of the Skene glands. Giant condyloma acuminatum Giant condyloma acuminatum or Buschke-Loewenstein tumor of the perianal or anorectal regions is a rare entity. Generally, such lesions are large-sized and aggressive, prone to ulceration and infiltration into deeper tissues. Figure Giant condyloma acuminatum. Contrast-enhanced, multiplanar MRI T2-weighted A,B and T1-weighted C,D sequences of the pelvis demonstrating multiple cauliflower-like verrucous lesions in the anogenital region arrows.

After contrast medium injection, marked contrast uptake by the lesion was observed. Vaginal endometriosis Endometriosis is defined by the presence of endometrial glands and stroma outside the uterine cavity. Frequently, it is found in pelvic fibromuscular structures such as uterosacral ligaments and ovaries.

Vaginal location is frequent and may manifest with deep dyspareunia and dysmenorrhea 9 Figure Multiplanar MRI T1-weighted B and T2-weighted A,C,D sequences of the pelvis demonstrating the presence of a focus of endometriosis with low signal intensity in the vaginal dome bold arrows , with signs of local tissue retraction and extension to the anterior wall of the rectum, characterizing infiltrative endometriosis intermingled with a focus of high signal intensity corresponding to hemorrhagic focus thin arrow.

V, vagina; R rectum. Other primary tumors are mainly adenocarcinoma, melanoma Figure 13 and sarcomas Spinocellular carcinoma. Axial A,B , coronal C and sagittal D multiplanar MRI T2-weighted sequences showing the presence of a solid, lobulated mass in the posterior and right lower vaginal walls V. The tumor infiltrates the rectovaginal fat plane arrows. Vaginal melanoma. Sagittal A1 and axial B1 MRI T2-weighted sequences showing the presence of a lobulated mass with low signal intensity arrows affecting the anterior and posterior vaginal walls, extending throughout its entire length up to the vaginal ostiuml.

MRI of another patient - contrast-enhanced T1-weighted sequence with fat saturation A2 demonstrates a hypervascular lesion deeply invading the vagina.

Staging: stage 0 - carcinoma in situ; stage I - tumor limited to the vaginal wall; stage II - tumor involving sub-vaginal tissue, without extension to the pelvic wall; stage III-tumor extending to the pelvic wall; stage IV - tumor extending to the true pelvis or involving the mucosa of the bladder or rectum; stage IV a - involvement of adjacent organs; IV b - involvement of distant organs.

Most commonly, ovaries, endometrium, uterine cervix and rectum are sites of origin of such neoplasms Figure Uterine cervix adenocarcinoma with locally invasive tumor. Sagittal A and axial B MRI T2-weighted sequences demonstrating a heterogeneous and infiltrative lesion extending towards the vaginal dome, rectovaginal septum and mesorectal fascia arrows.

V, vagina; U, uterus. Vaginal metastasis from ovary adenocarcinoma - Axial A1 and sagittal B1 multiplanar MRI T2-weighted sequences demonstrate lymph node enlargement asterisk and peritoneal carcinomatosis, including an infiltrating lesion in the vaginal dome arrows. V, vagina. Vaginal metastasis from endometrial carcinoma - Axial A2 and sagittal B2 MRI T2-weighted sequences demonstrating the primary tumor filling the endometrial cavity U and a well-defined nodule skip lesions with intermediate signal intensity in the right anterior wall of the vagina arrow.

Vaginal metastasis from uterine cervix squamous cell carcinoma - MRI T2-weighted A3 and contrastenhanced T1-weighted B3 sequences demonstrating ill-defined mass originating from the uterine cervix and extending towards the lower uterine segment and lower third of the vagina arrows. Main risk factors include multiparity, advanced age, menopause, obesity, conjunctival tissue diseases, smoking and chronic pulmonary obstructive disease.

The symptoms are related to urinary and bowel incontinence, and sexual dysfunction 11 Figure Pelvic floor prolapse. Sagittal A and dynamic axial B MRI T2-weighted sequences demonstrate large prolapse of the urogenital hiatus characterized by inversion of the vaginal dome, small bowel loops and abdominal fat protrusion. Post-radiotherapy complications. A1: Fistulous path thin arrows between the anterosuperior vaginal wall and the vesicouterine pouch.

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